Egg Freezing what Do you Hope to Accomplish?
The best approach motherhood is to actually try to get pregnant. Though methods of fertility preservation are very helpful, none is a guarantee to make a baby in the future. So the primary advice is “try to get pregnant if you can” after checking different fertility factors (male, tubal and ovarian factors as well preconception screening). If getting pregnant is not feasible in the short term, due to medical or social issues, egg freezing is considered. A reproductive endocrinologist is faced with the challenge of foreseeing if a specific woman, when stimulated and her eggs are harvested and frozen, has a reasonable potential to conceive using these eggs at one time in the future.
Indication for Egg Freezing
Women should consider egg freezing when specific medical or age related situations threatens their ability to have a child in the future.
1. Fertility preservation: When a medical disorder or its treatment can diminish ovarian reserve and reduce the chance for conception e.g cancer treatment (most common is breast cancer), lupus nephritis requiring treatment with chemotherapy, blood diseases requiring bone marrow transplantation, premature ovarian dysfunction and others. About 2 weeks should be available for an egg freezing cycle.
2. Fertility extension (no male partner): women with no male partner and declining the use of donor sperm can freeze their eggs to use in the future when in a committed relationship.
3. Fertility extension (with a male partner): women with a male partner can elect to freeze some of their eggs unfertilized. Unfertilized eggs are under the control of the woman alone, unlike embryos that cannot be used without the consent of both partners.
4. IVF with failed sperm retrieval or ejaculation: In some cases with male factor with failed retrieval of sperm from the testes or failed ejaculation, eggs can be frozen and used later when sperm are available.
5. Children undergoing treatment for cancer and other diseases with the ascent of their parents.
What should you consider before proceeding to egg freezing
i. Women <38 years with good ovarian reserve: are excellent candidates for egg freezing. Good reserve is indicated by antral follicle count >10 as seen on vaginal ultrasound and AMH levels > 1.75 ng/mL. They will likely produce a good number of oocytes to freeze in a single cycle. These eggs are relatively healthy as they are young. Age <36 years was the best predictor of egg freezing so far in scientific reports.
ii. Women <38 years with diminished ovarian reserve: are still good candidates for egg freezing. They produce lower number of eggs after stimulation but their oocytes are relatively healthy (chromosomally normal). They can undergo more than one cycle of egg freezing if the first cycle yields <8 mature eggs.
iii. Women 38-40 years with good reserve: can still consider egg freezing with no further delay.
vi. Women 38-40 years with diminished ovarian reserve: should consider egg freezing with caution. They will not produce a good number of eggs and may require multiple cycles of egg freezing.
V. Women >41y are not good candidates for egg freezing even if they have a good reserve as the majority of their oocytes are not chromosomally normal. Although pregnancies were reported from vitrified oocytes up to age 44, the chance of pregnancy in quite low in women older than 40.
Realistic Expectations for egg freezing
Not only should the number and quality of eggs be considered, but also the survival of thawed eggs, fertilization and ultimate ability to implant. These issues are very sensitive to the method of ovarian freezing. Vitrification (rapid freezing) is not the method of choice for low temperature storage of eggs due to high survival and subsequently fertilization and embryo development (more details here and here).
Survival on average 85% of virified thawed eggs survive, irrespective of age.
Fertilization approximately 80% of thawed eggs fertilize after injecting each with a sperm (ICSI).
Age specific chance for a live birth after thawing of vitrified eggs can be presented in different ways. The delivery rate is approximately 5 to 15% per thawed egg depending upon the female age at freezing. For example, if eggs are thawed and fertilized and three embryos were transferred to the uterus, the probability of delivery would be 25% at age 30 and 15% at age 40.
If a 35 year old decided to proceed with an egg freezing cycle and produced 10 eggs, 8 eggs were mature and frozen. When she present back 10 years later to utilize her eggs and thaw all of them 7 eggs are expected to survive, 6 eggs are expected to fertilize. If three embryos were transferred her chance for delivering a baby is 20% (the remaining three embryos are frozen). If The first cycle does not succeed and the next three embryos were transferred, her cumulative chance for having a baby from the original egg freezing cycle is approximately 40%.
Sorting through statistics of egg freezing is difficult. No single clinic can present convincing statistic due to small number of egg thaw and transfer (not just egg freezing cycles). Most studies present select donors and selected women and not directly applicable to everyone. And then there is the safety issue and lack of long term follow up data related to safety and health of newborns.
Age is most important predictive of success of egg freezing followed by method of freezing. Vitrification much better than older slow freezing methods. There is now reasonable body of data, though not definitive, that allows prediction of outcome for egg freezing using vitrification based on age and the expected number of retrieved oocytes. It is neither accurate nor scientific to label egg freezing with terms such as reliable and guarantee. It certainly is not a guarantee of children. What is more productive is to i. try to avoid egg freezing through trying to conceive. If not possible, in a short while, then ii. understand your own personal chances of delivering a healthy baby through egg freezing and if they seem reasonable to you consider the procedure, taking in consideration the limitation of available data and filtering out the marketing hype.Egg Freezing what Do you Hope to Accomplish? by Dr. Amr Azim